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PCOD is a condition in which ovaries produce many immature or partially mature eggs, this happen due to poor lifestyle, obesity, stress and hormonal imbalance. PCOS is a metabolic disorder and more severe form of PCOD can lead to anovulation where ovaries stop releasing eggs. Polycystic ovary syndrome (PCOS) is one of the most common female endocrine disorder that affects 6-15% of the female population It is primarily characterized by an extremely irregular menstrual cycle in which ovulation does not occur [2]. The major endocrine gland that involved in the PCOS are hypothalamus, pituitary gland, ovaries and adrenal gland and peripheral adipose tissue that together contribute to create a generally imbalance. Most symptoms first appear in adolescence around the start of menstruation. However, some women don`t develop symptoms until early-mid 20`s. It is also known as Stein-Leventhal syndrome or hyperandrogenic anovulation (HA). It also referred to as syndrome “O” that is over nourishment, overproduction of insulin, ovarian confusion and ovulatory disruption [2]. It is associated with the development of type-2 diabetes and recurrent miscarriage [3].
A PCOS patient ovaries contains more than ten follicles visible on ultrasound. The polycystic ovary, in comparison to normal ovary, its layer has more follicle and has a dense centre. This centre is known as stroma which is where testosterone made [4]. Generally, PCOS consist of the presence of any 3 criteria, oligo-anovulation, clinical or biochemical evidence of hyperandrogenism and the presence of polycystic ovaries on ultrasound examination. However, polycystic ovaries are non-specific finding noted in women with no endocrine or metabolic abnormalities. PCOS is one of leading cause of female subfertility and the most frequent endocrine problem in women of reproductive age. The cysts are not harmful but lead to hormone imbalances and cause problems of periods and make difficult to get pregnant. PCOS is medical condition in which there is an imbalance of female sex hormones. That is, elevated levels of testosterone, DHEA-S, androstenedione, prolactin and LH along with normal, high or low estrogen levels. Hyperinsulinemia, insulin resistance and impaired glucose tolerance are very common in women with PCOS but insulin resistance may occur in lean women with PCOS [7] National Institute of Health (NIH), it was recommended that the diagnostic criteria for PCOS involve the concomitant presence of anovulation and evidence of hyperandrogenaemia [8]. In clinical practice, 75% of women with PCOS suffer from anovulation infertility and 50% of them experience recurrent pregnancy loss. However, it not clear whether these defects are caused by uterine dysfunction itself or by the interrupted interaction between uterine cells and developing embryo. Young women with PCOS induced endometrial hyperplasia are more likely than non PCOS women to develop endometrial carcinoma. The precise etiology and pathogenesis of PCOS remain uncertain PCOS are commonly found by the use of ultrasound, magnetic resonance imaging (MRI) and computed tomography scanning (CT) . Ethology The exact cause of PCOS is unknown or heterogeneous in nature however it certainly linked to a variety of etiological factors . Insulin resistance PCOS is a multifaceted metabolic disorder that shows high association with insulin resistance leading the hyperinsulinemia, 10% show type-2 diabetes. 30-35% have impaired glucose tolerance (IGT). Result in increased production of testosterone lead to abnormal ovulation. Studies suggest that high activity levels of micro RNA in fat cell hinders the use of glucose by insulin contributing to PCOS and also insulin resistance [2] Hyperinsulinemia is probably the result of both increased insulin secretion and a decrease in insulin clearance. Anovulatory women with PCOS are relatively hyperinsulinaemic and more insulin resistant than ovulatory women with PCOS [4] Selective insulin resistance is central to the etiology of PCOS. Thus compensatory hyperinsulinaemia may result in a decreased level of serum hormone binding globulin (SHBG), and serve as a trophic stimulus to androgen production in the adrenals and ovaries and have a direct effect on hypothalamus causing an abnormally stimulated appetite and increased gonadotropin secretion. It includes reduced insulin receptor activity peripherally and leads to endocrine dysfunction of PCOS. Obesity amplifies the degree of insulin resistance and hyperinsulinaemia. 6.Insulin drives increased androgen production from the ovary and adrenal and may alter gonadotropin secretion. It is also responsible for decreased SHBG synthesis in the liver thus increasing free testosterone in the circulation. Ovarian insulin sensitivity to the prevailing hyperinsulinemia is thought to be one of the mechanisms that drives ovarian androgen production. Body mass index, hyperandrogenaemia, and clinical hyperandrogenism are independent predictors of insulin resistance [10]. Altered steroid negative feedback regulation of LH together with the compensatory hyperinsulinemia due to insulin resistance may disrupt ovulatory function, causing anovulation . The polycystic ovary disorder (PCOS) is characterized as a mix of hyperandrogenism (hirsutism and skin break out) and anovulation (oligomenorrhea, barrenness, and useless uterine seeping), with or without the nearness of polycystic ovaries on ultrasound. It speaks to the primary endocrine issue in the conceptive age, influencing 6% - 15% of ladies in threats. It is the most widely recognized reason for barrenness because of anovulation, and the primary wellspring of female fruitlessness. At the point when in the pre-since of a menstrual issue, the finding of PCOS is come to in 30% - 40% of patients with essential or auxiliary amenorrhea and in 80% of patients with oligomenorrhea. PCOS ought to be analyzed and treated right off the bat in pre-adulthood because of conceptive, metabolic and ontological difficulties which might be related with it. Treatment choices incorporate medications, diet and way of life improvement. For solid youthful couples, the probability of getting pregnancy differs. In 2010, an expected 48.5 million couples worldwide were barren. This paper gives a survey on barrenness causes, examinations, treatment modalities and job of medical attendant birthing specialist in managing fruitless couples. Barrenness (a condition of sub richness) can be showed either as the failure to wind up pregnant, powerlessness to maintain a pregnancy, and failure to proceed with a pregnancy till term. There are different reasons for female and male fruitlessness.
hyperandrogemism is: hirsutism, androgenic alopecia, skin break out, acanthuses Nigerians. Hirsutism: It might be a clinical indication of hyperandrogenism. The wisdom of the closeness of hirsutism as an issue relies upon social and ethnic segments. Cause by hair development Upper lip Chin Chest Upper back Lower back Upper midriff Upper arm Forearm Thigh or leg Polycystic ovaries on ultrasound: Ultrasound is the premier extensively used technique for the ultrasound examination of PCO. The sonographic criteria have been thusly balanced and, along these lines, the addition in ovarian volume (>10 cm3) and the proximity of >12 follicles with a broadness of 2 to 9 mm at smallest in one ovary [13]. In extension to these criteria, other restorative conditions that can cause steady an ovulation and androgen excess should be restricted, for example, Hyperprolactinemia/hyperthyroidism Congenital adrenal hyperplasia, traditional and no established structure Cushing's disorder; secretary ovarian tumor of adrenal androgens Polycystic Ovarian Syndrome of Pathophysiology: The polycystic ovary mess is the overwhelming visit pathology ladies of regenerative age. It was delineated for the fundamental time by Stein and Leventhal in 1935. There is Heterogeneity of clinical introduction, eccentricity of signs absolutely assorted age groups, covering instrumental and research office symptomatic criteria with physiological conditions and along these lines require cut off shared and vital in clinical hone . Sing and symptoms: Irregular periods Acne Hair loss or hair thinning on scalp. Excessive bleeding during the periods. No periods Excessive facial or bodily hair. Eggs do not ovulate. Infertility or difficulty in becoming pregnant. Enlarged ovaries with cysts. Increase the sugar. Darkening of the skin. Undemeath the breasts. Depression Anxiety Mood swings Irritation Unpredictable periods: Most common periods, on ordinary, are somewhere in the range of 28 and 32 days. Anything shorter than 21 days or longer than 35 days is viewed as flighty. Its creation ponderousness of female sex hormones .Sporadic or truant period is the preeminent normal symptom [12].Skin break out: A kept up polymorphic dermatitis by a deep rooted aggravation of the hair follicle. It's a bacterial malady of smooth skin, or potentially dandruff [1 ] .Hair incident from head: PCOS is hair adversity or the lessening of hair. Etiology/cause: The exact reason for PCOS is dark; it is gotten on to be a multi factorial condition with a genetic part. Around 20– 40% of first-degree female relatives of women with PCOS proceed to make PCOS themselves, contrasted with evaluated 4– 6% prevalence inside the normal people [18] .The fundamental driver of PCOS: Genetic inclination Life style Environments Increased insulin Increased androgens Increased estrogen Irregular periods Weakened resistant framework Bead dietary Dirty nourishment Hormonal awkwardness Inflammation Confusion of pcos: The confusion is partitioned into basically three sorts: A. Early-term complexity B. Obstetric complexities C. Long-term complexities A. Early-term complexity: Barrenness: Fruitlessness was a standout amongst the most signs at first credited to the PCOS agreeing to the essential depiction. PCOS is the chief basic reason for adulatory mess and oligoanovulation is connected with extended possibility for unprofitability. Vanity has been considered by the World Wellbeing Organization (WHO) as an open prosperity issue. One of the focal destinations of the UN Conference Modified of Activity on Populace and Advancement in 2015 was to guarantee, for all individuals, get to quality regenerative prosperity organizations [19]. Barrenness is the premier confusion of early-term difficulty. It was point by point a superior rate of polycystic appearance of the ovary (PCO) on US in patients with standard ovulatory yet sub ripe and repeated pregnancy disaster [20]. The theoretical regenerative oddities identified with the turmoil, the available thinks about dependent on cutting edge PCOS expressive criteria and with test sizes enough enormous seemed to report conflicting comes about the need of clear data. Obstetric complexities/Pregnancy entanglement: The unused symptomatic criteria, the inside has moved to regenerative issues, tallying too the obstetrics intricacies. The extended rate of pregnancy inconveniences in women with PCOS can be the consequence of a couple of factors, for example, PCOS features, fruitlessness prescriptions, diverse pregnancies, chubbiness, IR and metabolic brokenness, exacerbation, and placental adjustment [1, 5]. It is still discussed whether women with PCOS have an extended peril of unexpected labor contrasted with women without PCOS. Inside the PCOS understanding 2012, ineffective work rates are proposed to be equivalent between women with and without PCOS, wound up pregnant by using ovulation acknowledgment sedates that can modify the opportunity of fruitless work contrasted with women with trademark origination C. Long-term intricacies: I. Cardiovascular hazard II. Metabolic hazard III. Oncology hazard Cardiovascular hazard: As point by point by the most coherent social requests women with PCOS show an extended power of great possibility segments for cardiovascular disease. In 2004, an around the globe case-control consider of patients from 52 countries was appropriated [25]. The 95% peoples CVD sway an in the first place myocardial dead tissue in women. The nine factors included smoking, hypertension, dyslipidemia, diabetes, instinctive chubbiness, psychosocial factors, lessened use of weight, psychosocial parts, reduced use of regular items and vegetables, ordinary usage of alcohol, and standard physical Metabolic hazard: Corpulence is viewed as a certifiable creating scourge mess inside the world masses, especially inside the adolescence and youthful quite a while 60%. The 10% unfamiliar diabetes and 35-45% blocked glucose obstruction. Women with PCOS who have constant anovulation however normal androgen levels tend to not be insult safe [27]. Women whit PCOS and metabolic issue or sorts 2 diabetes are at the most raised danger of CVD. The blend of anovulation and hyperinsulinemia can progress endometrial cell development, growing the opportunity of endometrial carcinomas and different varieties from the standard [28]. A contemplate led in Brazil, concerning power of hypertension in women with and without PCOS, revealed a twofold transcendence of the messiness in women with PCOS. The extended peril of hypertensive state seems, by all accounts, to be illuminated by IR and hyperinsulinemia, common of PCOS that alter vascular smooth muscle cells causing hypertrophy of vascular muscle divider with diminished consistence and by the impedances inside the endothelium- subordinate vasodilatation instruments . III. Oncology hazard: Since PCOS is considered as an enduring multisystem and multifaceted mess, the regenerative and metabolic changes portraying the turmoil might be also related with an extended shot of the improvement of malignancies, for example, the endometrial, ovarian, and bosom disease, which perceive potential hormonal as well as metabolic
pathogenesis instruments. The potential segments which may propel the beginning of neoplastic ailments in these women, particularly endometrial malignant growth, fuse the steady anovulatory state, coming to fruition in an unopposed estrogen movement, related with hyperandrogenism .The women with PCOS of any age give off an impression of being at an extended danger of endometrial malignant growth. In explicit, the risk of endometrial malignant growth might be undoubtedly higher inside the premenopausal subgroup of women with PCOS, while for the most part the possibility of ovarian and bosom disease was not basically extended . Different disarranges: In development to surely understood cardiovascular and metabolic impedances, patients with PCOS show an extended possibility for mental messes and lessened personal satisfaction (QoL) contrasted with sound women. , it has been discovered that the prevalence rates of demoralization in PCOS stretch out from 14% to 67%, with a fourfold increasingly noticeable odds of burdensome signs contrasted and age-coordinated control women. The composing showed up an extended power of summed up uneasiness and an addition in unfeeling uneasiness scores in women with PCOS contrasted and control women . The Clinic Uneasiness and Misery Scale, the Beck Uneasiness Stock, and the Beck Misery Stock, that evaluates the repeat of mental signs in uneasiness and trouble, independently, that incorporates examination of sentiments, hirsutism influence, weight, menstrual disarranges, and unproductiveness . Diagnosis of pcos: Polycystic ovary issue (PCOS) could be a perplexing condition that is most routinely broke down by the closeness of two of the three taking after criteria: oligo-or anovulation, by then hyperthyroidism, hypothyroidism, hyperprolactinemia, hypogonadotropic hypogonadism, and less than ideal ovarian dissatisfaction must be kept away from. If the peaceful accompanies hirsutism, by then late- beginning natural adrenal hyperplasia, androgen-emitting ovarian tumor, androgen-discharging adrenal tumor, Cushing issue and exogenous androgen use must be disallowed . Assurance required pathognomonic ovarian endings and the clinical arrangement of three of hirsutism, amenorrhea, and chunkiness Hyperandrogenism: Hyperandrogenism is a key component of PCOS. Despite the fact that the adrenal organ may contribute, hyperandrogenism is primarily ovarian in starting point among ladies with an essential analysis of PCOS. In different populaces around the globe, it has been discovered that most ladies with PCOS have raised dimensions of serum androgens; be that as it may, typical dimensions might be found in certain ladies. For an analysis of PCOS, it is adequate to have raised serum androgen levels or an organic articulation of hyperandrogenism (skin break out or hirsutism). Heftiness: 40% to half of ladies with PCOS are hefty. This heftiness is typically of the android type, with expanded midsection to-hip proportions. Whenever present, corpulence exacerbates insulin obstruction and expands the hazard for diabetes and cardiovascular malady. The treatment of stoutness ought to be a noteworthy focal point of preventive social insurance for ladies with PCOS. Nonetheless, weight reduction in such patients is hard to accomplish. This might be expected to a limited extent to a debilitation of adiposity lipolysis, which thusly is connected to insulin obstruction . The Ovarian Diagnosis: The polycystic ovary is effectively analyzed. It is expanded, typically more noteworthy than 9 mL with in excess of 8 mL incidentally situated cystic structures (10 mm) in a sonographic plane encompassed by an expanded stromal mass (25% of the ovarian volume) . Nonetheless, in spite of the fact that we and others have demanded these severe criteria, a sonographic range exists. Polycystic ovaries may at times be missing in ladies with the majority of the other great clinical qualities of PCOS [36]. The symptomatic workup should start with a careful history and physical examination. Clinicians should concentrate on the patient's menstrual history, any vacillations in the patient's weight and their effect on PCOS indications, and coetaneous discoveries (e.g., terminal hair, skin break out, alopecia, acanthosis Nigerians, and skin labels). Patients ought to likewise be gotten some information about variables identified with basic co morbidities of PCOS .As indicated by the Rotterdam criteria, determination requires the nearness of no less than two of the accompanying three discoveries: hyperandrogenism, ovulatory brokenness, and polycystic ovaries. A solitary ovary meeting either or both of these definitions is adequate for finding of polycystic ovaries Different tests that might be useful yet are a bit much for analysis incorporate estimation of LH and follicle invigorating hormone (FSH) levels to decide a serum proportion of LH/FSH. A proportion more prominent than 2 for the most part show PCOS, yet there are no accurate cutoff esteems in light of the fact that a wide range of tests are utilized. The FSH level is progressively useful in decision out ovarian disappointment. Administrations of PCOS: PCOS the executive’s zones include: Lifestyle: Lifestyle change, including hypo caloric diet and physical exercise, is viewed as a foundation of the administration of ladies with PCOS giving heftiness, especially the stomach phenotype [1]. Solid way of life practices' incorporating smart dieting and ordinary physical action ought to be prescribed in each one of those with PCOs keep up sound weight upgrade, hormonal results, general welllbeing, and personal satisfaction over the existence course. Weight reduction International Journal of Trend in Scientific Research and Development (IJTSRD) objectives indispensable (5-10% body weight), center around: diminishing in general caloric admission. Day by day morning exercise 30 mints. Clinical hyperandrogenism (eg-hirsutism): Cosmetic choices: laser hair expulsion, depilatory creams, stringing, culling, waxing and electrolysis. Agreeing Pharmacological treatment choices hostile to androgen (6 a year to see advantage) :( the best first-line treatment for gentle hirsutism is oral contraceptives. Spironolactone, 100 mg every day, and flutamide, 250 mg twice day by day, are ok for patient use, yet the proof for their adequacy is insignificant . Menstrual cycle guideline: Lifestyle endeavors can improve cycle consistency. The Endocrine Society suggests hormonal contraception (i.e., oral preventative, dermal fix, or vaginal ring) as the underlying drug for treatment of unpredictable menses . Joined oral preventative pill (COCP).COCP pills increment SHBG consequently decreasing free androgens; give contraception, endometrial insurance and cycle guideline. Metformin – improves ovulation, restores cycles, and decreases insulin opposition. Decreases movement to diabetes, may forestall weight gain. Liquor abundance maintained a strategic distance from on metformin taken. Pharmacological treatments for fruitlessness incorporate letrozole or clomiphene, however in essential consideration, metformin can be begun before ripeness pro referral educating ladies that it isn't as successful. Metformin: Metformin is utilized when insulin opposition is a known or associated cause with barrenness, normally in ladies with an analysis of PCOS. Metformin improves insulin obstruction, which can improve the probability of ovulation. Letrozole: Letrozole (Femoral) has a place with a class of medications known as aromatase inhibitors and works likewise to clomiphene, Letrozole may instigate ovulation. Weight the board: focusing on avoidance of weight gain, accomplishing no less than 5-10% weight reduction if overweight. Conduct change – prioritization of sound way of life, family backing, way of life and exercise arranging, defining of little attainable objectives. Calorie shortage of 500-750 cal every day required for weight reduction (for example 1200-1500 cal day by day admission), with nobody diet favored. 250 min moderate exercise/week or 150 min vivacious exercise/week required for weight reduction [38]. There is constrained information on its impact on pregnancy intricacies. Weight reduction ought to be accomplished with way of life change by caloric limitation and expanded physical exercise. Diminished caloric admission by 500-1000 kcal/day has been proposed to be viable, going for decreasing the body weight by 7-10% over a time of 6 a year. Organized moderate exercise going on for 30 minutes or more for every day is prudent .
Cardio metabolic wellbeing: smoking – guidance end, BP: check every year, Lipid profile at pattern on the off chance that BMI >25, at that point as indicated by and large CVD hazard: check each 2-4 years. Diabetes: 3-5 overlap expanded hazard and before beginning of gestational, prediabetes and diabetes in PCOS; these likewise happen in lean and in youthful PCOS ladies . Mental and passionate wellbeing: In ladies with PCOS there is a high pervasiveness of moderate to extreme tension and burdensome manifestations. Screen for tension and burdensome manifestations at analysis. Dietary issues, negative self- perception, low confidence and psychosexual brokenness ought to likewise be considered. In the case of screening is sure, evaluate chance variables and side effects utilizing a suitable appraisal instrument treatment is required, consider a Mental Health Treatment Plan , continuous help as well as referral to a psychological wellness proficient. 8. Conclusion: The Rotterdam 2003 study are unclear and relatively poorly characterized. It ought to likewise be perceived that any distinctions from typical are mode stat best. The NIH 1990 criteria, these information propose that this gathering of people might be at more serious hazard for the metabolic results, including type 2 DM, contrasted and sound controls, in spite of the fact that this remaining parts to be affirmed. This is a heterogeneous disorder, both regarding clinical introduction and research center signs. Ladies with PCOS have been exhibited a more serious danger of endometrial disease, which is identified with the alienate increment and the high pervasiveness of anovulatory cycles which support the endometrial hyperplasia, as it is as of now known. The overweight is likewise connected to this sort of malignant growth and speaks to, accordingly, an extra hazard factor for endometrial disease in these patients . The additionally detailed the heftiness job in the event of PCOS and its fruitlessness connection. By and large, ladies with PCOS demonstrate an expanded danger of obstetric, cardiovascular, metabolic, and mental confusions contrasted with non-PCOS ladies. These dangers don't have a similar substance in all PCOS subjects and can change amid life. This inconstancy appears to be firmly identified with PCOS phenotypes. In any case, the pathogenesis instrument which joins PCOS to the high rate of early-term and long haul confusions isn't completely known. The equivalent PCOS- related hormonal and metabolic highlights, for example, hyperandrogenism, IR and related hyperinsulinemia, and instinctive weight, assume a critical job in expanding these dangers however the definite components with which they act have not yet been totally illustrated. PCOS is affected by the race since ethnic contrasts happen in both the metabolic phenotype social models of conduct, likely adding to the varying articulations of PCOS, with unmistakable effect on QoL of these ladies, just as on the long haul results . Acknowledgements: I feel very froud to say that due to course these article. First of all would like thanks them to all for help this article course. Clinical hyperandrogenism (eg-hirsutism): Cosmetic choices: laser hair expulsion, depilatory creams, stringing, culling, waxing and electrolysis. Agreeing Pharmacological treatment choices hostile to androgen (6 a year to see advantage) :( the best first-line treatment for gentle hirsutism is oral contraceptives. Spironolactone, 100 mg every day, and flutamide, 250 mg twice day by day, are ok for patient use, yet the proof for their adequacy is insignificant . Menstrual cycle guideline: Metformin: Metformin is utilized when insulin opposition is a known or associated cause with barrenness, normally in ladies with an analysis of PCOS. Metformin improves insulin obstruction, which can improve the probability of ovulation. Assessment of Lifestyle and Diet Modification of Patients Suffering from Polycystic Ovarian Disease (PCOD) in North India On the one hand, it’s a well-known fact that the root cause of PCOD has a substantial hereditary factor, and is often transmitted from mother to daughter. Barbieri is one of the first persons to study about PCOD [9]. According to the author, PCOD is a common endocrinopathy in women of reproductive age. Regarding the genetic connection of PCOD a few studies in literature are relevant. Battaglia et al. discovered that polycystic ovaries in childhood may be considered a sign of genetic predisposition to PCOD and that environmental influences may express the adult clinical and hormonal presentation of the syndrome. Study conducted by Vink et al. also showed that the contribution of familial component in PCOD is due to genetic factors. On the other hand, many studies have suggested that lifestyle modification and dietary treatment of women with PCOD was the best initial management for obese women seeking to improve their reproductive function. Study of lifestyle modifications by use of alteration of diet intake and exercise therapy to treat obese women with PCOD were successfully employed by Palomba et al. study of association of PCOD with the sociodemographic variables of the PCOD suffering patients based on the different categories of nourishment levels is lagging in the literature. Thus, we set the objectives of the present study as: to assess the general, anthropometric, biochemical, clinical, lifestyle and dietary pattern of the patient suffering from PCOD and to compute the association of PCOD with certain demographic variables at different levels of nourishments. Also we hypothesize that there will be a significant association between the patients suffering from PCOD with different demographic variables. To our knowledge, this is the first study of this kind conducted in the Indian sub- continent.
2. Materials and Methods 2.1. Research Settings Descriptive approach is utilized in this study. The study is conducted in Krishna Hospital of Kanpur, Uttar Pradesh, India. The population of study is the female diagnosed with PCOD and undergoing treatment. The sample size is 50. 2.2. Statistical Analysis Non-probability convenient sampling technique is used in this study. Structured questionnaire is used to collect the data. The plan for data analysis is carried out using descriptive statistics and inferential statistics. The investigation is carried further to find out the association between lifestyle and diet modification in the development of PCOD with selected demographic variables. information like age, religion, lifestyle, occupation, education level, family history of PCOD, income group, menstruation duration, marital status and reproductive issues (if any) from the participants. Bio-chemical results of Luteinizing hormone to Follicle-stimulating hormone (LH-FSH) ratio was also acquired from the patients. Anthropometrical data were collected in terms of body height, weight and BMI. Finally the clinical examination of the participants with the help of experienced physicians and nurses was carried out. The general appearance, hair quality, appetite, face skin and body hair was observed and the participants were categorized into different sub-groups based on that scrutiny. 2.4. Dietary Assessment Dietary data are acquired by recording the information of food consumed by patients in 3 consecutive days. 24-hour dietary recall sessions for 3 days was used for the information. The reported information of food quantities in terms of plates, bowls and glasses was converted into equivalent scientific quantities of grams and calories by following a standard conversion technique. 2.5. Nutritional Status Nutritional status of the patients was assessed according to various demographic variables. The participants are classified as under-nourished (Ur), Nourished (Nr) and Over- nourished (Or) based on the dietary data. 3. Results The information obtained from the survey of patients is used to classify them into different categories on the basis of various demographic variables. Table 1 demonstrates the percentage of women belonging to different groups and sub- groups based on general, bio-chemical, anthropometric and clinical examinations. It is revealed that more than two-third women in survey were of age group 20-40 years and almost the same proportion of women had sedentary lifestyle. In terms of occupation, 58% of the women were house-wives while 28% were working as employee and rest had their own businesses. The information about the education level showed that only 12% were college graduates while almost a quarter of the participants were illiterate. Correspondingly, while we asked them about the family history of PCOD (if any). 4. Discussion of the Results The objectives of the present study were to assess the anthropometric, biochemical, clinical, life-style and dietary pattern of the patient suffering from PCOD and to compute the association of PCOD with certain demographic variables of the same categories. To our knowledge, this is the first study in the Indian sub-continent to access the sociodemographic variables of PCOD suffering patients and to estimate the association of PCOD with these variables by classifying the patients into different categories of nourishment level. Initially, the general information of patients under survey was collected. Age, religion, life-style, occupation, education level, income level, etc. of the patients was inquired. The main motivation for this study is to get the overview of the group of patients suffered from PCOD and getting treatment at Krishna Hospital, Kanpur in North India. Further analysis of results regarding the life-style and occupation of the patients revealed that, majority of them were having sedentary life-style and main stream were house-wives. A significant comparison between these aspects and their suffering from PCOD can be made. A hypothesis of relation between the physical activities of the patients and their suffering from PCOD is also revealed from association analysis as well. However, the study of some variables were not successful for example an attempt to perceive the association between PCOD suffering and family history of the same couldn’t be made precisely because almost half of the patients didn’t have idea regarding their family history. Nevertheless, some well-established facts like menstruation duration and reproductive health related issues during PCOD gave consistent results. In the similar manner, anthropometry of the patients is carried out. BMI of majority of the patients was observed to be more than the recommended safe value. Clinical examination of appearance, hair, face and skin revealed some interesting data. It is observed that majority of the patients have good general appearance. Similarly, discolour and dry hair is observed for around a quarter of the patients. Additionally, alopecia is observed for majority of the patients under survey. Moreover, half of the patients were having normal appetite while anorexia was observed for almost remaining half. Similarly, the skin observation of the patients revealed that 50% of them were having Hyperkeratosis and Phrynoderma. Hair related issues including face and body hair was observed in a few patients as well. Next, dietary information of the patients was collected and analysed. 50% of them were found to be vegetarian. It was also revealed that majority of those who have non- vegetarian food use to consume the same once in a week. Moreover, 85% of those who consume non-vegetarian food were fond of white meat rather than red meat. The patients’ preference of food revealed that almost all of them like sweet food. Majority of them like salty food and very few of them like spicy and sour food. Additionally, 70% of the patients said that they like consuming junk food occasionally. Information regarding the oil used by them for cooking revealed that they use either refined oil or mustard oil. Similarly, cooking method adopted by them as well as habit of eating fruits and green leafy vegetables is also studied. Life-style of the patients including the habits of smoking and alcohol consumption is enquired. It was socking to notice that many patients (around 78%) never perform any sorts of physical exercise or yoga. In the similar manner, chronic diseases suffering in the patients of PCOD is discussed. 18% of them were suffering from CVD while 32% of them were suffering from diabetes. Around 44% of them were not suffering from any chronic diseases.
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